Chen Wang

 Ph.D.

  Computational Bioinformatics and Bio-imaging Laboratory(CBIL)
  Electrical and Computer Engineering, Virginia Tech

  Address:    900 N. Glebe Road, 4-214
                      Arlington, VA 22203
  Phone:       571-858-3152
  Email:        topsoil@vt.edu

  Trained as a statistical signal processing guy in wireless communication area,
I was deeply impressed by the mystery of biological system and attempted to
understand it through mathematical and engineering modelling. My current research
focuses on utilizing/developing signal processing and machine learning approches
a) to analyze high-dimensional genomic data, such as microarray, ChIP-chip, Copy
Number Change; b) to facilitate the biological discovery through multiple data integration,especially in disease study. It's always my pleasure to look back and forth between signal processing/machine learning theory and real biological problem, to recognize the discrepancy and find out consistency.

 

Education

Aug. 2006 -  June 2011

 Ph.D. Student, Electrical and Computer Engineering, Virginia Tech

Sept. 2003 - Jul 2006

 M.S., Electrical Engineering, Univ. of Sci. and Tech. of China

Sept. 1998 - Jul 2003

 B.S., Electrical Engineering,  Univ. of Sci. and Tech. of China

[Top]

Research Interests

Computational Genomics

- Computational dissection of composite molecular signatures and modules (mNCA)

- Gene regulatory network modeling

Pattern Recognition and Machine Learning

- Statistical signal processing

- Genetic network & pathway inference

- Data integration

[Top]

Publications

Journal Publications


C. Wang, J. Xuan, I.-M. Shih, R. Clarke, and Y. Wang, "Regulatory component analysis: a semi-blind extraction approach to infer gene regulatory networks with imperfect biological knowledge," Signal Processing, 2011. (accepted)

C. Wang, S. Ha, Y. Wang, E. Hoffman, and J. Xuan, "Computational analysis of muscular dystrophy subtypes using a novel integrative scheme," Neuocomputing, 2011. (accepted)

C. Wang, J. Xuan, H. Li, Y. Wang, M. Zhan, E. P. Hoffman and R. Clarke, "Knowledge-guided gene ranking by coordinative component analysis," BMC Bioinformatics, 11:162, 2010.

I.-M. Shih, L. Chen, C. Wang, J. Gu, B. Davidson, L. Cope, R. J. Kurman, J. Xuan, and T.-L. Wang, "Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis," Am J Obstet Gynecol., 203(6):584, 2010.

L. Chen, J. Xuan, C. Wang, I.-M. Shih, T.-L. Wang, Z. Zhang, R. Clarke, E. Hoffman and Y. Wang, "Biomarker identification by knowledge-driven multi-level ICA and motif analysis," Intl J. Data Mining and Bioinformatics, vol. 3, no. 4, pp. 365-381, 2009.

C. Wang, J. Xuan, L. Chen, P. Zhao, Y. Wang, R. Clarke, and E. P. Hoffman, "Motif-directed network component analysis for regulatory network inference,"BMC Bioinformatics,vol. 9, (S1):S21, 2008

L. Chen, J. Xuan, C. Wang, I.-M. Shih, Y. Wang, Z. Zhang, E. Hoffman, and R. Clarke, "Knowledge-guided multi-scale independent component analysis for biomarker identification," BMC Bioinformatics, 9:416, 2008.

T. Gong, J. Xuan, C. Wang, H. Li, E. Hoffman, R. Clarke, and Y. Wang, "Gene module identification from microarray data using nonnegative independent component analysis," Gene Regulation and Systems Biology,vol. 1, pp. 349-363, 2007.

Conference Publications

J. Gu, C. Wang, I.-M. Shih, T.-L. Wang, Y. Wang, R. Clarke, and J. Xuan, "A Gibbs Sampler to Identify Intracellular Signal Transduction Pathways," to appear in Proc. IEEE International Conference of the Engineering in Medicine and Biology Society (EMBC11), Boston, MA, Aug. 2011.

C. Wang, J. Xuan, L. L. Chen, R. B. Riggins, E. P. Hoffman, and R. Clarke, "Reliability Analysis of Transcriptional Regulatory Networks," in Proc. Intl Conf. on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, Orlando, FL, July 2008.

J. Xiong, C. Wang, B. Zhang, Y. Wang, E. P. Hoffman, R. Clarke, and J. Xuan, "Inferring Condition-Specific miRNA-Gene Modules from miRNA and mRNA Profiling Data," in Proc. Intl Conf. on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, Orlando, FL, July 2008.

C. Wang, J. Xuan, L. L. Chen, P. Zhao, Y. Wang, R. Clarke, and E. P. Hoffman, "Integrative Network Component Analysis for Regulatory Network Reconstruction," in Proc. Fourth Intl Symposium on Bioinformatics Research and Applications, pp. 196-207, Atlanta, Georgia, May 2008.

L. L. Chen, C. Wang, I.-M. Shih, T.-L. Wang, Z. Zhang, Y. Wang, R. Clarke, E. Hoffman and J. Xuan, "Biomarker Identification by Knowledge-Driven Multi-Level ICA and Motif Analysis," Proc. Sixth Intl Conf. on Machine Learning and Applications, pp. 560-566, Cincinnati, Ohio, Dec. 2007.

C. Wang, J. Xuan, T. Gong, R. Clarke, E. Hoffman, Y. Wang, "Stability Based Dimension Estimation of ICA with Application to Microarray Data Analysis," Proc. The 2007 Intl Conference on Bioinformatics & Computational Biology, vol. 1, pp. 132-138, Las Vegas, Nevada, June 2007.

[Top]

Others

  Google site homepage

Last Updated: Dec. 2, 2009